Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual Disease https://t.co/xljvg929gq
— Chris Hourigan (@DrChrisHourigan) December 20, 2019
Presidential Early-Career Award for Scientists and Engineers
The Presidential Early-Career Award for Scientists and Engineers (PECASE) is the highest honor given by the U.S. government to outstanding scientists and engineers who are beginning their independent research careers and who show exceptional promise for leadership in science and technology.
EHA 2019 Interviews
Heterogeneity in Refractory AML
Published today – result of great collaboration between the Gottesman (NCI) and Hourigan (NHLBI) labs at NIH using fantastic dataset generated from BeatAML 1.0 effort.
Congrats to Gege, Blair and our new friends in the Gottesman lab.
Munich 2019 Interviews
On a roll…
The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.
Lab co-author: Katie Lindblad
Molecular Measurable Residual Disease Testing of Blood During AML Cytotoxic Therapy for Early Prediction of Clinical Response.
Lab first author: Hong Yuen
Lab co-authors: Katie Lindblad, Sheenu, Greg, Meg, Matt, Nestor, Jingrong, Julie, Blair, Laura and Katie Lai.
MDS-associated mutations in germline GATA2 mutated patients with hematologic manifestations.
Lab Co-authors: Hong Yuen, Jingrong, Matt.
Refining AML outcome prediction.
With more to come soon….
Dr Haydar Celik joins lab as research scientist.
Human bone marrow by scRNA-seq, CyTOF and Flow
Our first pre-print! Congratulations to Kary Oetjen and rest of lab on what we hope will be a useful reference dataset – deep assessment of human bone marrow from twenty healthy human donors aged 24-84 by paired single-cell RNA-sequencing and multi-parameter 13-color flow cytometry (with mass cytometry as orthogonal validation of T and NK immunophenotype). Due-diligence benchmarking prior to our use of this technology on clinical trial samples shows great opportunity for proteogenomics/CITE-Seq/REAP-seq/Ab-Seq to help better resolve T and NK cell populations. Uploading dataset now – enjoy!
RNA-Seq for AML MRD
Single NGS assay to track APL, CBF AML and NPM1mutated AML to very high sensitivity (1 in 100,000 in some cases). Qiagen kit of this assay coming soon.
Four generations of Hourigan Lab postbacs!
27th July 2018
An unexpected pleasure of the lab leaving party was having four generations of lab postbacs all in one place!
In order, from left to right:
Jack Ghannam 2018-Present
Katie Lindblad 2016-2018 (now PhD student, Mt. Sinai)
Matt Mulé 2014-2016 (now MD-PhD student, UNC and OxCam)
Meg Goswami 2012-2014 (now PhD student, GW-NIH)